From time to time, my Desktop folder icons (the default "Home" and "Computer" icons) fail to open with a left-button double click. I also have "Directory Menu" in my panel that similarly fails to respond to a left-button single click. At about this time, the widows start trailing when I move them. At least I can access the menu! In fact, the only way I can navigate my system graphically is to go to Menu > Accessories > File Manager.
It doesn't seem like this is a file manager (pcmanfm) problem since I can still use pcmanfm through the Menu > Accessories > File Manager. Maybe the display manager (LXDM) or window manager (Openbox)?
When my system starts this behavior, it get really, really slow. The only solution I have found to date is to restart my computer.
My LM12 LXDE is pretty much a stock installation (i.e., very little tweaking).
I also posted in another section, but I believe my issue might well be different than what is being discussed here: viewtopic.php?f=8&t=31360&start=10#p38822